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Title

Therapeutic potential of CB2 targeting in multiple sclerosis

AuthorsDocagne, Fabian ; Mestre, Leyre ; Loría, Frida ; Hernangómez-Herrero, Miriam ; Correa, Fernando Gabriel ; Guaza, Carmen
KeywordsCannabinoid
CB2 receptor
Multiple sclerosis
Neuroinflammation
Neuroprotection
Theiler's murine encephalomyelitis virus
Issue Date2008
PublisherAshley Publications
CitationExpert Opinion on Therapeutic Targets 12(2): 185-195 (2008)
AbstractBackground: Cannabinoids have been shown to exert beneficial actions in different animal models of multiple sclerosis (MS). However, the use of cannabinoids compounds in human therapy is greatly limited by their psychoactivity. Thus, new hopes in MS therapy have arisen from the evidence for a cannabinoid receptor, termed CB2, which is devoid of psychoactive effects in animal models. Objective: This review discusses the different mechanisms by which CB2 activation could induce therapeutic actions in MS. Methods: Particular focus is given to the potential effects on inflammation/autoimmunity, remyelination and neuroprotection. Conclusion: This review discusses the importance of glial cells in sustaining these effects, as well as the putative secondary effects that would limit the use of CB2 agonists in the treatment of MS. © 2008 Informa UK Ltd.
Publisher version (URL)http://doi.org/10.1517/14728222.12.2.185
URIhttp://hdl.handle.net/10261/63330
DOI10.1517/14728222.12.2.185
Identifiersdoi: 10.1517/14728222.12.2.185
issn: 1472-8222
Appears in Collections:(IC) Artículos
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