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FTIR microspectroscopic analysis of the effects of certain drugs on oxidative stress and brain protein structure

AuthorsCarmona, Pedro ; Rodríguez-Casado, Arantxa; Álvarez-Vicente, María Isabel ; Miguel, E. de; Toledano Gasca, Adolfo
Issue Date2008
PublisherJohn Wiley & Sons
CitationBiopolymers 89: 548- 554 (2008)
AbstractThis study reports the changes in lipids and proteins of different brain areas of nicotine. D(+)-amphetamine, and nicotine and D(+)-amphetamine treated rats by monitoring lipid peroxidation and protein β-sheet formation using infrared microspectroscopy. Compared with the untreated brain samples, the peroxide level is relatively higher in the amphetamine-treated brain sections, both in the cortex and hippocampus area. However, this peroxide increase is attenuated when administering amphetamine plus nicotine. Analogous drug-dependent trends for protein β-sheet content are observed, which suggests a connection between lipid oxidation involved in oxidative stress and β-sheet protein structure generally present in neurodegenerative diseases. The above property of nicotine is of interest, in the sense that it might reduce the production of β-amyloid proteins in Alzheimer's disease. © 2008 Wiley Periodicals, Inc.
Identifiersdoi: 10.1002/bip.20944
issn: 0006-3525
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