Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/63185
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Lima, Margarida | - |
dc.contributor.author | Almeida, Julia | - |
dc.contributor.author | Balanzategui, Ana | - |
dc.contributor.author | Bárcena, Paloma | - |
dc.contributor.author | Bueno, Clara | - |
dc.contributor.author | González, Marcos | - |
dc.contributor.author | San Miguel, Jesús F. | - |
dc.contributor.author | Orfao, Alberto | - |
dc.date.accessioned | 2012-12-18T13:51:20Z | - |
dc.date.available | 2012-12-18T13:51:20Z | - |
dc.date.issued | 2003 | - |
dc.identifier | issn: 0002-9440 | - |
dc.identifier | e-issn: 1525-2191 | - |
dc.identifier.citation | American Journal of Pathology 163(2): 763-771 (2003) | - |
dc.identifier.uri | http://hdl.handle.net/10261/63185 | - |
dc.description.abstract | Large granular lymphocyte (LGL) leukemia is a well-recognized disease of mature T-CD8+ or less frequently natural killer cells; in contrast, monoclonal expansions of CD4+ T-LGL have only been sporadically reported in the literature. In the present article we have explored throughout a period of 56 months the incidence of monoclonal expansions of CD4+ T-LGL in a population of 2.2 million inhabitants and analyzed the immunophenotype and the pattern of cytokine production of clonal CD4+ T cells of a series of 34 consecutive cases. Like CD8+ T-LGL leukemias, CD4+ T-LGL leukemia patients have an indolent disease; however, in contrast to CD8+ T-LGL leukemias, they do not show cytopenias and autoimmune phenomena and they frequently have associated neoplasias, which is usually determining the clinical course of the disease. Monoclonal CD4+ T-LGL showed expression of TCRαβ, variable levels of CD8 (CD8-/+dim) and a homogeneous typical cytotoxic (granzyme B+, CD56+, CD57+, CD11b+/-) and activated/memory T cell (CD2+bright, CD7-/+dim, CD11a+bright, CD28-, CD62L- HLA-DR+) immunophenotype. In addition, they exhibited a Th1 pattern of cytokine production [interferon-γ++, tumor necrosis factor-α++, interleukin (IL-2)-/+, IL-4-, IL-10-, IL-13-]. Phenotypic analysis of the TCR-Vβ repertoire revealed large monoclonal TCR-Vβ expansions; only a restricted number of TCR-Vβ families were represented in the 34 cases analyzed. These findings suggest that monoclonal TCRαβ+/CD4+/NKa+/CD8-/ +dim T-LGL represent a subgroup of monoclonal LGL lymphoproliferative disorders different from both CD8+ T-LGL and natural killer cell-type LGL leukemias. Longer follow-up periods are necessary to determine the exact significance of this clonal disorder. | - |
dc.description.sponsorship | Comissão de Fomento da Investigação em Cuidados de Saúde, Ministério da Saúde, Portugal PI 51/99; Acção Integrada Luso-Espanhola E31/99, Conselho de Reitores das Universidades Portuguesas, Ministério da Educação, Lisboa, Portugal; Acción Integrada Hispano-Lusa HP1998-0091, Dirección General de Enseñanza Superior e Investigación Científica, Ministerio de Educación y Cultura, Madrid, Spain, FIS 99/1240; Ministerio de Sanidad y Consumo, Madrid, Spain; FIS 02/1244; Ministerio de Sanidad y Consumo, Madrid, Spain, and SA103/03, Consejería de Educación y Cultura, Junta de Castilla y León, Valladolid, Spain; and the University of Salamanca (grant Reg. N. 430 to P. B.). | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Investigative Pathology | - |
dc.publisher | Elsevier | - |
dc.rights | closedAccess | - |
dc.title | TCRαβ+/CD4+ large granular lymphocytosis: A new clonal T-cell lymphoproliferative disorder | - |
dc.type | artículo | - |
dc.date.updated | 2012-12-18T13:51:20Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
268
checked on 18-abr-2024
Download(s)
33
checked on 18-abr-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.