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dc.contributor.authorMatesanz, F.-
dc.contributor.authorFernández, Óscar-
dc.contributor.authorMilne, Roger L.-
dc.contributor.authorFedetz, María-
dc.contributor.authorLeyva, Laura-
dc.contributor.authorGuerrero, Miguel-
dc.contributor.authorDelgado, Concepción-
dc.contributor.authorLucas, Miguel-
dc.contributor.authorIzquierdo, Guillermo-
dc.contributor.authorAlcina, Antonio-
dc.date.accessioned2012-12-18T12:21:57Z-
dc.date.available2012-12-18T12:21:57Z-
dc.date.issued2008-
dc.identifierdoi: 10.1016/j.jneuroim.2008.01.004-
dc.identifierissn: 0165-5728-
dc.identifiere-issn: 1872-8421-
dc.identifier.citationJournal of Neuroimmunology 195(1-2): 146-150 (2008)-
dc.identifier.urihttp://hdl.handle.net/10261/63160-
dc.description.abstractSome polymorphisms in the FCRL3 gene, a member of the Fc-receptor like family, have been associated with several autoimmune diseases and recently with multiple sclerosis (MS). We performed a case-control study of three SNPs in FCRL3 gene in 645 MS patients and 786 controls, all Caucasians from the South of Spain. Genotype and allele frequencies of two SNPs (rs7528684/FCRL3_3 and rs7522061/N28D), which were in high linkage disequilibrium (r2 = 0.87), differed between MS cases and controls. The C allele of FCRL3_3 was found to be protective for MS (per allele OR = 0.81, 95% C.I. = 0.70-0.94; P-value = 0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3. © 2008 Elsevier B.V. All rights reserved.-
dc.description.sponsorshipThis work was supported by Grants Plan Nacional SAF2006-02023 from MEC to A. Alcina and PI041298 to F. Matesanz, CP03/0042 to L. Leyva and PAI CTS-507 to O. Fernández. M. Fedetz is a holder of a fellowship from Fundación IMABIS.-
dc.language.isoeng-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.titleThe high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis-
dc.typeartículo-
dc.identifier.doi10.1016/j.jneuroim.2008.01.004-
dc.date.updated2012-12-18T12:21:57Z-
dc.description.versionPeer Reviewed-
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