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Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid

AuthorsMarcos, I. S.; Basabe, Pilar; Mollinedo, Faustino ; Iglesia-Vicente, Janis de la; Sierra, Beatriz G.
Issue Date2007
CitationBioorganic and Medicinal Chemistry 15(17): 5719-5737 (2007)
AbstractSeveral sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC50 in the low micromolar range. © 2007 Elsevier Ltd. All rights reserved.
Identifiersdoi: 10.1016/j.bmc.2007.06.007
issn: 0968-0896
Appears in Collections:(IBMCC) Artículos
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