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Interaction of dexamethasone and montmorillonite

AuthorsForteza González, M.; Galán Huertos, Emilio; Cornejo, J.
Issue DateSep-1987
PublisherSociedad Española de Arcillas
CitationThe Sixth meeting of the European Clay Groups: 223-225 (1987)
AbstractClay-drug interactions have been widely studied during the last decade. However, the reaction mechanisms responsible of these interactions only have been elucidated in sorne cases (1,2), most of them when cationic drugs are ínvolved. Neutral molecules are known to interact with clays by physical adsorption (3), and/or by hydrogen bonding (4). Dioxin is adsorbed onto montmorillonite by a reversible adsorption mechanism (5) and degrades by acid-catalyzed hydrolisis. The mechanism of ad sorption and degradation of the neutral steroid hydrocortisone by palygorskite and sepio1ite has be en recently studied (6,7). Two types of ferric iron present in these clays may be responsible for the different degradation rates of hydrocortisone.
Description3 pages, 1 figure, 7 references.-- Congreso celebrado del 7-10 septiembre 1987 en Sevilla, España.-- EUROCLAY'87.
Appears in Collections:(IRNAS) Comunicaciones congresos
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