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http://hdl.handle.net/10261/63125
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Iglesia-Vicente, Janis de la | - |
dc.contributor.author | Mollinedo, Faustino | - |
dc.date.accessioned | 2012-12-18T11:02:39Z | - |
dc.date.available | 2012-12-18T11:02:39Z | - |
dc.date.issued | 2010 | - |
dc.identifier | doi: 10.1021/jm901373w | - |
dc.identifier | issn: 0022-2623 | - |
dc.identifier | e-issn: 1520-4804 | - |
dc.identifier.citation | Journal of Medicinal Chemistry 53(3): 983-993 (2010) | - |
dc.identifier.uri | http://hdl.handle.net/10261/63125 | - |
dc.description.abstract | Several series of nonlactonic podophyllic aldehyde analogues were prepared and evaluated against several human tumor cell lines. They had different combinations of aldehyde, imine, amine, ester, and amide functions at C-9 and C-9′ of the cyclolignan skeleton. All the compounds synthesized showed cytotoxicity levels in the μM range and below. Within the new series tested, compounds having an aldehyde or imine at C-9 and an ester at C-9′ were the most potent, with GI50 values in the nM range, some of them being several times more potent against HT-29 and A-549 carcinoma than against MB-231 melanoma cells. Cell cycle studies and analysis of the microtubule-disrupting capacity have demonstrated the existence of two different mechanisms of cell death induction for compounds with closely related structures. © 2010 American Chemical Society. | - |
dc.description.sponsorship | Financial support came from Spanish Ministerio de Ciencia y Tecnología (CTQ2008-02899, SAF2008-02251), Red Temática de Investigación Cooperativa en Cáncer, Instituto de Salud Carlos III (RD06/0020/1037), and Junta de Castilla y León (SA 005A08 and fellowship to M. V.R.). We thank Dr. H. B. Broughton for his help with proofreading. | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.rights | closedAccess | - |
dc.title | Synthesis and Biological Evaluation of New Podophyllic Aldehyde Derivatives with Cytotoxic and Apoptosis-Inducing Activities | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1021/jm901373w | - |
dc.date.updated | 2012-12-18T11:02:40Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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