Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/63070
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorMéndez-Lagares, Gema-
dc.contributor.authorPozo-Balado, Maria del Mar del-
dc.contributor.authorGenebat, Miguel-
dc.contributor.authorGarcía-Pergañeda, A.-
dc.contributor.authorLeal, Manuel-
dc.contributor.authorPacheco, Yolanda M.-
dc.date.accessioned2012-12-17T13:41:16Z-
dc.date.available2012-12-17T13:41:16Z-
dc.date.issued2012-
dc.identifierdoi: 10.1093/infdis/jis230-
dc.identifierissn: 0022-1899-
dc.identifier.citationJournal of Infectious Diseases 205: 1501-1509 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/63070-
dc.description.abstractWe hypothesized that CD4 +CD25 hiFoxP3 + regulatory T cells (Tregs) could be involved in the high immune activation existing in patients with low-level CD4 T-cell repopulation under suppressive high active antiretroviral therapy (hereafter, >LLR patients>). Sixteen LLR patients, 18 human immunodeficiency virus (HIV)-infected controls (hereafter, >HIV controls>), and 16 healthy subjects were included. The frequency of CD4 +CD25 hiFoxP3 + and HIV-specific Treg suppressive function were assessed. Relationships between Treg and CD4/CD8 activation (HLA-DR/CD38) and the frequency of naive CD4 T-cells were assessed. Low-level patients showed a higher Treg frequency but reduced HIV-specific immunosuppressive functions than HIV controls. Whereas in healthy subjects a strong negative correlation between Tregs and activated CD8 T cells emerged (r =-0.75, P <. 001), it appeared disrupted in both HIV-infected groups (r =-0.06 and P =. 83 for LLR patients; r =-0.11 and P =. 68 for and HIV controls). Nevertheless, in LLR patients, Tregs negatively correlated with naive CD4 T cells (r =-0.60, P =. 01), whereas there was no such correlation in HIV controls (r =-0.19, P =. 46) or healthy subjects (r =-0.10, P =. 73). Remarkably, a higher ratio of Tregs to naive CD4 T cells was observed in LLR patients than in HIV controls (P =. 001) and healthy subjects (P <. 001). We conclude that LLR patients have important alterations in immunoregulation involving CD4 +CD25 hiFoxP3 + Tregs. In this scenario, the role of Tregs seems to be more related to the control of the naive CD4 T-cell homeostatic proliferation, rather than to the immune activation. © 2012 The Author.-
dc.language.isoeng-
dc.publisherUniversity of Chicago Press-
dc.rightsclosedAccess-
dc.titleSevere immune dysregulation affects CD4 +CD25 hiFoxP3 + regulatory T cells in HIV-infected patients with low-level CD4 T-Cell repopulation despite suppressive highly active antiretroviral therapy-
dc.typeartículo-
dc.identifier.doi10.1093/infdis/jis230-
dc.date.updated2012-12-17T13:41:17Z-
dc.description.versionPeer Reviewed-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
Aparece en las colecciones: (IBIS) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

SCOPUSTM   
Citations

46
checked on 19-mar-2024

WEB OF SCIENCETM
Citations

46
checked on 17-feb-2024

Page view(s)

326
checked on 28-mar-2024

Download(s)

110
checked on 28-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.