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dc.contributor.author | Méndez-Lagares, Gema | - |
dc.contributor.author | Pozo-Balado, Maria del Mar del | - |
dc.contributor.author | Genebat, Miguel | - |
dc.contributor.author | García-Pergañeda, A. | - |
dc.contributor.author | Leal, Manuel | - |
dc.contributor.author | Pacheco, Yolanda M. | - |
dc.date.accessioned | 2012-12-17T13:41:16Z | - |
dc.date.available | 2012-12-17T13:41:16Z | - |
dc.date.issued | 2012 | - |
dc.identifier | doi: 10.1093/infdis/jis230 | - |
dc.identifier | issn: 0022-1899 | - |
dc.identifier.citation | Journal of Infectious Diseases 205: 1501-1509 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/63070 | - |
dc.description.abstract | We hypothesized that CD4 +CD25 hiFoxP3 + regulatory T cells (Tregs) could be involved in the high immune activation existing in patients with low-level CD4 T-cell repopulation under suppressive high active antiretroviral therapy (hereafter, >LLR patients>). Sixteen LLR patients, 18 human immunodeficiency virus (HIV)-infected controls (hereafter, >HIV controls>), and 16 healthy subjects were included. The frequency of CD4 +CD25 hiFoxP3 + and HIV-specific Treg suppressive function were assessed. Relationships between Treg and CD4/CD8 activation (HLA-DR/CD38) and the frequency of naive CD4 T-cells were assessed. Low-level patients showed a higher Treg frequency but reduced HIV-specific immunosuppressive functions than HIV controls. Whereas in healthy subjects a strong negative correlation between Tregs and activated CD8 T cells emerged (r =-0.75, P <. 001), it appeared disrupted in both HIV-infected groups (r =-0.06 and P =. 83 for LLR patients; r =-0.11 and P =. 68 for and HIV controls). Nevertheless, in LLR patients, Tregs negatively correlated with naive CD4 T cells (r =-0.60, P =. 01), whereas there was no such correlation in HIV controls (r =-0.19, P =. 46) or healthy subjects (r =-0.10, P =. 73). Remarkably, a higher ratio of Tregs to naive CD4 T cells was observed in LLR patients than in HIV controls (P =. 001) and healthy subjects (P <. 001). We conclude that LLR patients have important alterations in immunoregulation involving CD4 +CD25 hiFoxP3 + Tregs. In this scenario, the role of Tregs seems to be more related to the control of the naive CD4 T-cell homeostatic proliferation, rather than to the immune activation. © 2012 The Author. | - |
dc.language.iso | eng | - |
dc.publisher | University of Chicago Press | - |
dc.rights | closedAccess | - |
dc.title | Severe immune dysregulation affects CD4 +CD25 hiFoxP3 + regulatory T cells in HIV-infected patients with low-level CD4 T-Cell repopulation despite suppressive highly active antiretroviral therapy | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1093/infdis/jis230 | - |
dc.date.updated | 2012-12-17T13:41:17Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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