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dc.contributor.author | Castelán, Francisco | - |
dc.contributor.author | Castillo-Paterna, Mar | - |
dc.contributor.author | Mulet, José | - |
dc.contributor.author | Sala, Salvador | - |
dc.contributor.author | Sala, Francisco | - |
dc.contributor.author | Domínguez del Toro, Eduardo | - |
dc.contributor.author | Criado, Manuel | - |
dc.date.accessioned | 2012-12-17T13:26:41Z | - |
dc.date.available | 2012-12-17T13:26:41Z | - |
dc.date.issued | 2008 | - |
dc.identifier | doi: 10.1111/j.1471-4159.2007.05169.x | - |
dc.identifier | issn: 0022-3042 | - |
dc.identifier | e-issn: 1471-4159 | - |
dc.identifier.citation | Journal of Neurochemistry 105: 617-627 (2008) | - |
dc.identifier.uri | http://hdl.handle.net/10261/63064 | - |
dc.description.abstract | The RIC-3 protein acts as a regulator of acetylcholine nicotinic receptor (nAChR) expression. In Xenopus laevis oocytes the human RIC-3 (hRIC-3) protein enhances expression of α7 receptors and abolishes expression of α4β2 receptors. In vitro translation of hRIC-3 evidenced its membrane insertion but not the role as signal peptide of its first transmembrane domain (TMD). When the TMDs of hRIC-3 were substituted, its effects on nAChR expression were attenuated. A certain linker length between the TMDs was also needed for α7 expression enhancement but not for α4β2 inhibition. A combination of increased α7 receptor steady state levels, facilitated transport and reduced receptor internalization appears to be responsible for the increase in α7 membrane expression induced by hRIC-3. Antibodies against hRIC-3 showed its expression in SH-SY5Y and PC12 cells and its induction upon differentiation. Immunohistochemistry demonstrated the presence of RIC-3 in rat brain localized, in general, in places where α7 nAChRs were found. © 2007 The Authors. | - |
dc.description.sponsorship | This work was supported by Grants from the Ministry of Education and Science of Spain and FEDER (BMC2002-00972, SAF2002-00209, SAF2002-02731, SAF2005-00534 and SAF2005-02045) and Generalitat Valenciana (GRUPOS03/038). FC was the recipient of a pre-doctoral fellowship (No. 153783) of the Consejo Nacional de Ciencia y Tecnología from México. | - |
dc.language.iso | eng | - |
dc.publisher | Blackwell Publishing | - |
dc.rights | closedAccess | - |
dc.title | Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/j.1471-4159.2007.05169.x | - |
dc.date.updated | 2012-12-17T13:26:42Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
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