Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/63011
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Gil-Sanz, Cristina | - |
dc.contributor.author | Delgado-García, José María | - |
dc.contributor.author | Fairén, Alfonso | - |
dc.contributor.author | Gruart, Agnès | - |
dc.date.accessioned | 2012-12-17T08:42:00Z | - |
dc.date.available | 2012-12-17T08:42:00Z | - |
dc.date.issued | 2008 | - |
dc.identifier | doi: 10.1093/cercor/bhm193 | - |
dc.identifier | issn: 1047-3211 | - |
dc.identifier | e-issn: 1460-2199 | - |
dc.identifier.citation | Cerebral Cortex 18(7): 1653-1663 (2008) | - |
dc.identifier.uri | http://hdl.handle.net/10261/63011 | - |
dc.description.abstract | Metabotropic glutamate receptor 1 (mGluR1) has been related to processes underlying learning in hippocampal circuits, but demonstrating its involvement in synaptic plasticity when measured directly on the relevant circuit of a learning animal has proved to be technically difficult. We have recorded the functional changes taking place at the hippocampal CA3-CA1 synapse during the acquisition of an associative task in conscious mice carrying a targeted disruption of the mGluR1 gene. Animals were classically conditioned to evoke eyelid responses, using a trace (conditioned stimulus [CS], tone; unconditioned stimulus [US], electric shock) paradigm. Acquisition of this task was impaired in mutant mGluR1+/- mice and abolished in mGluR1-/- mice. A single pulse presented to Schaffer collaterals during the CS-US interval evoked a monosynaptic field excitatory postsynaptic potential at ipsilateral CA1 pyramidal cells, whose slope was linearly related to learning evolution in controls but not in mGluR1 mutants. Long-term potentiation evoked by train stimulation of Schaffer collaterals was also impaired in both mGluR1 +/- and mGluR1-/- animals. Administration of the selective mGluR1 antagonist (3aS,6aS)-6a-naphthalen-2-ylmethyl-5-methyliden-hexahydro- cyclopental [c]furan-1-on to wild-type animals mimicked the functional changes associated to mGluR1 insufficiency in mutants. Thus, mGluR1 is required for activity-dependent synaptic plasticity and associative learning in behaving mice. © The Author 2007. Published by Oxford University Press. All rights reserved. | - |
dc.description.sponsorship | Spanish Ministry of Education and Science (BFU2004-04660 to A.F., BFU2005-01024 to J.M.D.-G., and BFU2005-02512 to A.G.). Generalitat Valenciana, Spain (CTBPRB/2003/156 to C.G.-S.). | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.rights | closedAccess | - |
dc.title | Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1093/cercor/bhm193 | - |
dc.date.updated | 2012-12-17T08:42:00Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IN) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
53
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
49
checked on 25-feb-2024
Page view(s)
309
checked on 24-abr-2024
Download(s)
92
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.