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Title

Iron deficiency and overload. Implications in oxidative stress and cardiovascular health | Deficiencia y sobrecarga de hierro; implicaciones en el estado oxidativo y la salud cardiovascular

AuthorsToxqui, Laura ; De Piero, A.; Courtois, V.; Bastida, Sara; Sánchez-Muniz, F. J.; Vaquero, M. Pilar
Issue Date2010
PublisherAula Médica Ediciones
CitationNutricion Hospitalaria 25: 350- 365 (2010)
AbstractAlthough iron is an essential mineral for maintaining good health, excessive amounts are toxic. Nowadays, much interest is focused on the mechanisms and regulation of iron metabolism by down-regulation of the hormone hepcidin. The HAMP gene encodes for hepcidin appears to be exceptionally preserved. Disorders of iron metabolism could lead to iron overload, mainly causing the rare disease hereditary hemochromatosis, or on the other hand, iron deficiency and iron deficiency anaemia. Currently, these alterations constitute an important problem of public health. The genetic variation implicated in iron overload and iron deficiency anaemia, involves mutations in several genes such as HFE, TFR2, HAMP, HJV, Tf and TMPRSS6. Iron has the capacity to accept and donate electrons easily and can catalyze reactions of free radicals production. Therefore, iron overload causes lipid peroxidation and increases cardiovascular risk. Recently, a relationship between iron metabolism and insulin resistance and obesity has been described. In contrast, regarding a possible relationship between iron deficiency anaemia and cardiovascular disease, many aspects remain controversial. This review presents an overview of the most recent information concerning iron metabolism, iron bioavail-ability and iron overload/deficiency related diseases. The relation between iron and cardiovascular risk, in iron overload and in iron deficiency situations, is also examined. Finally, strategies to modify dietary iron bioavail-ability in order to prevent iron deficiency or alleviate iron overload are suggested.
URIhttp://hdl.handle.net/10261/62962
DOI10.3305/nh.2010.25.3.4583
Identifiersdoi: 10.3305/nh.2010.25.3.4583
issn: 0212-1611
Appears in Collections:(IF) Artículos
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