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dc.contributor.author | Winograd, Milena | - |
dc.contributor.author | Destexhe, Alain | - |
dc.contributor.author | Sánchez-Vives, María V. | - |
dc.date.accessioned | 2012-12-14T11:26:18Z | - |
dc.date.available | 2012-12-14T11:26:18Z | - |
dc.date.issued | 2008 | - |
dc.identifier | doi: 10.1073/pnas.0800360105 | - |
dc.identifier | issn: 0027-8424 | - |
dc.identifier | e-issn: 1091-6490 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America 105(20): 7298-7303 (2008) | - |
dc.identifier.uri | http://hdl.handle.net/10261/62954 | - |
dc.description.abstract | We describe a phenomenon of hyperpolarization-activated graded persistent activity (HAGPA) in prefrontal cortex neurons. Successive hyperpolarizing pulses induced increasingly higher rates of tonic firing that remained stable for tens of seconds, allowing the neuron to retain a memory of the previous history of stimulation. This phenomenon occurred at the cellular level and in the absence of neuromodulators. Neurons with HAGPA had a sag during hyperpolarization, and blocking h-current eliminated the sag and prevented HAGPA, suggesting that the activation of this hyperpolarization-activated cationic current was necessary for the occurrence of the phenomenon. A single-neuron biophysical model including h-current modulation by intracellular calcium was able to display HAGPA. This form of neuronal memory not only allows the transformation of inhibition into an increase of firing rate, but also endows neurons with a mechanism to compute the properties of successive inputs into persistent activity, thus solving a difficult computational problem. © 2008 by The National Academy of Sciences of the USA. | - |
dc.description.sponsorship | This work was supported by the Ministerio de Educación y Ciencia (M.V.S.-V.), the Human Frontier Science Program (A.D. and M.V.S.-V.), the Centre National de la Recherche Scientifique (A.D.), and the European Commission (A.D.). M.W. had a PhD fellowship from Formación de Personal Investigador (Ministerio de Educación y Ciencia). | - |
dc.language.iso | eng | - |
dc.publisher | National Academy of Sciences (U.S.) | - |
dc.rights | closedAccess | - |
dc.title | Hyperpolarization-activated graded persistent activity in the prefrontal cortex | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1073/pnas.0800360105 | - |
dc.date.updated | 2012-12-14T11:26:18Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 18474856 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
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