Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/62870
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Subgroups of parkinsonian patients differentiated by peptidergic immunostaining of caudate nucleus biopsies |
Autor: | Ceballos, María L. de CSIC ORCID; López-Lozano, J. J. | Fecha de publicación: | 1999 | Editor: | Elsevier | Citación: | Peptides 20: 249- 257 (1999) | Resumen: | In this study, Met-enkephalin (Met-enk), substance P (SP) and tyrosine hydroxylase (TH) immunostaining was assessed in caudate nucleus biopsies from 15 Parkinson's disease patients who were treated surgically. According to the combination of changes in Met-enk, SP and TH immunostaining, several subgroups of parkinsonian patients were disclosed. Group I: Patients showing low SP and normal Met-enk immunostaining, and variably reduced TH immunoreactivity. Group II: both SP and Met-enk immunostaining were apparently of normal intensity in these PD patients, but they showed the greatest decrease in TH labeling. Group III: PD patients that showed normal SP, very low Met-enk and variably reduced TH immunostaining. Low Met-enk immunostaining tended to correlate with the severity of the disease as judged by higher Unified Parkinson's disease Rating Scale and gait scores. These results suggest that different neurochemical phenotypes may exist among Parkinson's disease patients. Peptidergic deficits should be taken into account for therapeutic intervention. | URI: | http://hdl.handle.net/10261/62870 | DOI: | 10.1016/S0196-9781(98)00177-6 | Identificadores: | doi: 10.1016/S0196-9781(98)00177-6 issn: 0196-9781 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
16
checked on 01-abr-2024
WEB OF SCIENCETM
Citations
16
checked on 18-feb-2024
Page view(s)
285
checked on 18-abr-2024
Download(s)
108
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.