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dc.contributor.authorRozalén, Ana E.-
dc.contributor.authorMoreno, Sergio-
dc.contributor.authorMartín-Castellanos, Cristina-
dc.identifierdoi: 10.1016/j.cub.2008.05.025-
dc.identifierissn: 0960-9822-
dc.identifiere-issn: 1879-0445-
dc.identifier.citationCurrent Biology 18(11): 849-854 (2008)-
dc.descriptionEl pdf del artículo es el manuscrito de autor.-- et al.-
dc.description.abstractMeiosis is a specialized nuclear division by which sexually reproducing diploid organisms generate haploid gametes. Recombination between homologous chromosomes facilitates accurate meiotic chromosome segregation [1] and is initiated by DNA double-strand breaks (DSBs) made by the conserved topoisomerase-like protein Spo11 (Rec12 in fission yeast) [2-4], but DSBs are not evenly distributed across the genome [5]. In Schizosaccharomyces pombe, proteinaceous structures known as linear elements (LinEs) are formed during meiotic prophase [6]. The meiosis-specific cohesin subunits Rec8 and Rec11 are essential for DSB formation in some regions of the genome [7], as well as for formation of LinEs or the related synaptonemal complex (SC) in other eukaryotes [8-12]. Proteins required for DSB formation decorate LinEs [13], and mutants lacking Rec10, a major component of LinEs, are completely defective for recombination [7, 11]. Although recombination may occur in the context of LinEs, it is not well understood how Rec10 is loaded onto chromosomes. We describe two novel components of LinEs in fission yeast, Rec25 and Rec27. Comparisons of rec25Δ, rec27Δ, and rec10Δ mutants suggest multiple pathways to load Rec10. In the major pathway, Rec10 is loaded, together with Rec25 and Rec27, in a Rec8-dependent manner with subsequent region-specific effects on recombination. © 2008 Elsevier Ltd. All rights reserved.-
dc.description.sponsorshipThis research was supported by grants from the National Institutes of Health to G.R.S. (GM032194), from the Spanish Ministry of Education and Science to S.M. (Consolider-Ingenio 2010 Programme CSD2007-00015), and from the Spanish Ministry of Health (FIS-FEDER 03/1193), Spanish Ministry of Education and Science (FEDER-BFU2007-66366), and Junta de Castilla y León (SA038A07) to C.M.-C. C.M.-C. is supported by the Spanish Ministry of Education and Science -FEDER (Ramón y Cajal Program).-
dc.titleRec25 and Rec27, Novel Linear-Element Components, Link Cohesin to Meiotic DNA Breakage and Recombination-
dc.description.versionPeer Reviewed-
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