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Changes in molecular isoform distribution of acetylcholinesterase in rat cortex and cerebrospinal fluid after intracerebroventricular administration of amyloid β-peptide

AuthorsSáez-Valero, Javier; Ceballos, María L. de ; Small, David H.; Felipe, Carmen de
Issue Date2002
CitationNeuroscience Letters 325: 199- 202 (2002)
AbstractPrevious studies have shown that an abnormal salt-soluble form of G1 acetylcholinesterase (AChE) is increased in the Alzheimer's disease (AD) brain. The aim of the present study was to examine changes in AChE activity in an in vivo model of β-amyloid peptide (Aβ) administration. Rats received intracerebroventricular injections of Aβ25-35 (20 μg/day for seven days). Levels of AChE were measured in cerebral cortex and cerebrospinal fluid (CSF) after two months. Aβ25-35 administration did not alter total AChE activity in the cerebral cortex or CSF. However, analysis of salt-extractable AChE isoforms revealed an increase in the proportion of G1 in both cortex and CSF, similar to that previously observed in AD patients. The results support the view that changes in AChE isoform pattern in the AD brain are a direct consequence of Aβ accumulation. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
Identifiersdoi: 10.1016/S0304-3940(02)00282-3
issn: 0304-3940
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