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Analgesic dipeptide derivatives. Part 8. 3-amino-2-hydroxy-4-[2-(o- nitrophenylthio)indol-3-yl]butanoic acid [AH(NPS)IBA]-containing dipeptide analogues of the analgesic compound H-Trp(Nps)-Lys-OMe

AuthorsHerranz, Rosario CSIC ORCID; Vinuesa, Soledad; Pérez, Concepción; García-López, M. T.; Ceballos, María L. de CSIC ORCID; Río, Joaquín del
Issue Date1991
CitationJournal of the Chemical Society, Perkin Transactions 1: 2749- 2755 (1991)
AbstractA series of diastereoisomeric dipeptides, analogues of the analgesic compound H-Trp(Nps)-Lys-OMe, containing 3-amino-2-hydroxy-4-[2-(o- nitrophenylthio)indol-3-yl]butanoic acid [AH(Nps)IBA] and Lys or Leu has been synthesized. These compounds were tested as aminopeptidase-M and -B (AP-M and AP-B) inhibitors and as analgesics. The AH(Nps)IBA-Leu dipeptides, independently of their stereochemistry, were poor inhibitors of AP-M and AP-B, with IC 50-values in the 10-4 mol dm-3 range, while the AH(Nps)IBA-Lys derivatives were poor AP-B inhibitors, with IC 50-values also in the 10-4 mol dm-3 range, and did not inhibit AP-M up to 10-3. All the AH(Nps)IBA-Lys derivatives induced a significant dose-related analgesic activity at 1-5 μg per mouse, which was dependent on the stereochemistry, while no analgesia was observed with the corresponding Leu-containing analogues. There is no relationship between the antinociceptive effects and the AP-M inhibitory potencies of this series of compounds, indicating that the inhibition of enkephalin-degrading AP-M is not an important factor for the mode of action of this series of analgesic dipeptides.
Identifiersdoi: DOI: 10.1039/P19910002749
issn: 1472-7781
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