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Título : Of man in mouse: modelling human cancer genotype-phenotype correlations in mice
Autor : Pérez-Caro, M.; Pérez-Mancera, P. A.; Voces, Felipe; Sánchez García, Isidro
Palabras clave : Mouse models
Drug discovery
Cancer process
Cancer target cell
Differentiation
Fecha de publicación : 2005
Editor: Bentham Science Publishers
Citación : Current Genomics 6(2): 81-88 (2005)
Resumen: To date, many genetic changes have been described and reported in the cancer process. Since the first mutations were described, several attempts to establish genotype-phenotype correlations for these genetic alterations have been reported. Moreover, in vitro data have suggested effects of mutant proteins in proliferation. Genotype-phenotype correlations are not only important for predicting the clinical course of the disease and to allow tailor-made surveillance of individuals at risk, but also have implications for the elucidation of the molecular genetic mechanisms underlying genesis of cancer and the development of gene-based therapies. Here, we discuss genotype-phenotype correlation of cancer in mouse and man, and the functional aspects that may account for these observations important to both understand and treat the human disease process.
Versión del editor: http://dx.doi.org/10.2174/1389202053642276
URI : http://hdl.handle.net/10261/6269
DOI: 10.2174/1389202053642276
ISSN: 1389-2029
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