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Prenylflavonoids and prenyl/alkyl-phloroacetophenones: Synthesis and antitumour biological evaluation

AuthorsBasabe, Pilar; Mollinedo, Faustino ; Sierra, Beatriz G.
Issue Date2010
CitationEuropean Journal of Medicinal Chemistry 45(9): 4258-4269 (2010)
AbstractSeveral prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active. © 2010 Elsevier Masson SAS. All rights reserved.
Identifiersdoi: 10.1016/j.ejmech.2010.06.025
issn: 0223-5234
Appears in Collections:(IBMCC) Artículos
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