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In vitro and in vivo reduced fitness and virulence in ciprofloxacin-resistant Acinetobacter baumannii

AuthorsSmani, Younes; López-Rojas, Rafael; Domínguez-Herrera, Juan; Docobo-Pérez, Fernando ; Marti, S.; Vila, Jordi; Pachón, Jerónimo
Issue Date2012
CitationClinical Microbiology and Infection 18(1): E1-E4 (2012)
AbstractLimited data on relative fitness and virulence of antimicrobial-resistant Acinetobacter baumannii are known. We aimed to study the virulence and fitness cost of ciprofloxacin-resistance in A. baumannii (CipR) compared with the susceptible parental wild-type strain (CipS). Human lung epithelial cells were infected with CipS and CipR for 24h. Competition fitness was monitored in vitro and in vivo in a murine peritoneal sepsis model. We showed that CipR induced less cell death than CipS and CipR growth was slow when in competition with CipS. Altogether, acquisition of ciprofloxacin resistance confers a biological fitness cost and reduces virulence in A. baumannii. © 2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases.
Identifiersdoi: 10.1111/j.1469-0691.2011.03695.x
issn: 1198-743X
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