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HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients

AuthorsGonzález-Serna, Manuel Alejandro; Romero-Sánchez, M.; Ferrando-Martínez, Sara; Genebat, Miguel; Vidal, Francesc; Muñoz-Fernandez, M. Angeles; Abad Arranz, María; Leal, Manuel; Ruiz-Mateos, Ezequiel
Issue Date2012
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 56(7): 3981-3983 (2012)
AbstractWe analyzed the evolution of viral tropism after 8 days of maraviroc monotherapy, i.e., we used the maraviroc clinical test (MCT), in 21 patients with and 14 without virological response to the drug (MCT + and MCT - patients, respectively). No increases in CXCR4 inferred viral loads (X4IVLs) were observed in MCT + patients, while X4IVLs increased only in MCT - patients, with X4IVLs of >2 log 10 HIV RNA copies/ml. These results shed light on the evolution of viral tropism under a CCR5 antagonist in vivo. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
Identifiersdoi: 10.1128/AAC.00507-12
issn: 0066-4804
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