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Título : SLUG (SNAI2) overexpression in embryonic development
Autor : Pérez-Mancera, P. A.; González-Herrero, Inés; Sánchez-Martín, M.; García, Juan L.; Robledo, Cristina; Flores, Teresa; Gutiérrez-Adán, A.; Pintado, Belén; Sánchez García, Isidro
Fecha de publicación : 2006
Citación : Cytogenetic and Genome Research 114(1): 24-29 (2006)
Resumen: The Snail-related zinc-finger transcription factor, SLUG (SNAI2), is critical for the normal development of neural crest-derived cells and loss-of-function SLUG mutations have been proven to cause piebaldism and Waardenburg syndrome type 2 in a dose-dependent fashion. However, little is known about the consequences of SLUG overexpression in embryonic development. We report SLUG duplication in a child with a unique de novo 8q11.2→q13.3 duplication associated with tetralogy of Fallot, submucous cleft palate, renal anomalies, hypotonia and developmental delay. To investigate the effects of Slug overexpression on development, we analyzed mice carrying a Slug transgene. These mice were morphologically normal at birth, inferring that Slug overexpression is not sufficient to cause overt morphogenetic defects. In the adult mice, there was a 20% incidence of sudden death, cardiomegaly and cardiac failure associated with incipient mesenchymal tumorigenesis. These findings, while not directly implicating Slug in congenital and acquired heart disease, raise the possibility that Slug overexpression may contribute to specific cardiac phenotypes and cancer development.
Versión del editor: http://dx.doi.org/10.1159/000091924
URI : http://hdl.handle.net/10261/6259
DOI: 10.1159/000091924
ISSN: 1424-8581
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