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Pegylated liposomal doxorubicin plus bortezomib in relapsed or refractory multiple myeloma: Efficacy and safety in patients with renal function impairment

AuthorsBladé, Joan; San Miguel, Jesús F.
Issue Date2008
CitationClinical Lymphoma and Myeloma 8(6): 352-355 (2008)
AbstractA retrospective analysis was undertaken of patients (n = 193) with renal insufficiency (creatinine clearance [CrCl] < 60 mL/min) from a phase III trial comparing bortezomib ± pegylated liposomal doxorubicin (PLD) in relapsed/refractory myeloma (n = 646). The response rate (49% vs. 42%) and median time to disease progression (331 days vs. 199 days) were comparable or slightly better for patients with renal insufficiency treated with PLD/bortezomib compared with patients treated with bortezomib alone. There was a steady, clinically meaningful improvement in renal function for patients with renal insufficiency in both treatment arms. However, patients with impaired renal function were at a slightly increased risk of a drug-related serious adverse event (28% vs. 19% for CrCl < 60 and ≥ 60 mL/min, respectively).
DescriptionThe DOXIL-MMY-3001 Study Investigators: et al.
Identifiersdoi: 10.3816/CLM.2008.n.051
issn: 1557-9190
Appears in Collections:(IBMCC) Artículos
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