English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/62406
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Molecular mechanisms controlling midline crossing by precerebellar neurons

AuthorsDi Meglio, T.; Nguyen Ba-Charvet, Kim; Tessier-Lavigne, M.; Sotelo, Constantino; Chédotal, Alain
Issue Date2008
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 28(25): 6285-6294 (2008)
AbstractPrecerebellar neurons of the inferior olive (IO) and lateral reticular nucleus (LRN) migrate tangentially from the rhombic lip toward the floor plate following parallel pathways. This process is thought to involve netrin-1 attraction. However, whereas the cell bodies of LRN neurons cross the midline, IO neurons are unable to do so. In many systems and species, axon guidance and cell migration at the midline are controlled by Slits and their receptor Robos. We showed previously that precerebellar axons and neurons do not cross the midline in the absence of the Robo3 receptor. To determine whether this signaling by Slits and the two other Robo receptors, Robo1 and Robo2, also regulates precerebellar neuron behavior at the floor plate, we studied the phenotype of Slit1/2 and Robo1/2/3 compound mutants. Our results showed that many IO neurons can cross the midline in absence of Slit1/2 or Robo1/2, supporting a role for midline repellents in guiding precerebellar neurons. We also show that these molecules control the development of the lamellation of the inferior olivary complex. Last, the analysis of Robo1/2/3 triple mutants suggests that Robo3 inhibits Robo1/2 repulsion in precrossing LRN axons but not in IO axons in which it has a dominant and distinct function. Copyright 2008 Society for Neuroscience.
Identifiersdoi: 10.1523/JNEUROSCI.0078-08.2008
issn: 0270-6474
e-issn: 1529-2401
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
Molecular Mechanisms Controlling.pdf699,83 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.