English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/62373
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing

AuthorsTrapp, Stefan; Aller, María Isabel; Wisden, William; Gourine, Alexander V.
Issue Date2008
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 28(35): 8844- 8850 (2008)
AbstractAcid-sensitive K+ channels of the tandem P-domain K +-channel family (TASK-1 and TASK-3) have been implicated in peripheral and central respiratory chemosensitivity; however, because of the lack of decisive pharmacological agents, the final proof of the role of the TASK channel in the chemosensory control of breathing has been missing. In the mouse, TASK-1 and TASK-3 channels are dispensable for central respiratory chemosensitivity (Mulkey et al., 2007). Here, we have used knock-out animals to determine whether TASK-1 and TASK-3 channels play a role in the carotid body function and chemosensory control of breathing exerted by the carotid body chemoreceptors. Ventilatory responses to hypoxia (10% O2 in inspired air) and moderate normoxic hypercapnia (3-6% CO2 in inspired air) were significantly reduced in TASK-1 knock-out mice. In contrast, TASK-3-deficient mice showed responses to both stimuli that were similar to those developed by their wild-type counterparts. TASK-1 channel deficiency resulted in a marked reduction of the hypoxia (by 49%)-and CO2 (by 68%)-evoked increases in the carotid sinus nerve chemoafferent discharge recorded in the in vitro superfused carotid body/carotid sinus nerve preparations. Deficiency in both TASK-1 and TASK-3 channels increased baseline chemoafferent activity but did not cause a further reduction of the carotid body chemosensory responses. These observations provide direct evidence that TASK-1 channels contribute significantly to the increases in the carotid body chemoafferent discharge in response to a decrease in arterial PO2 or an increase in PCO2 /[H+]. TASK-1 channels therefore play a key role in the control of ventilation by peripheral chemoreceptors. Copyright © 2008 Society for Neuroscience.
URIhttp://hdl.handle.net/10261/62373
DOI10.1523/JNEUROSCI.1810-08.2008
Identifiersdoi: 10.1523/JNEUROSCI.1810-08.2008
issn: 0270-6474
e-issn: 1529-2401
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
A Role for TASK-1.pdf376,18 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.