English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/62343
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Long-term ovariectomy enhances anxiety and depressive-like behaviors in mice submitted to chronic unpredictable stress

AuthorsLagunas, Natalia; Calmarza-Font, Isabel ; Diz-Chaves, Yolanda ; García-Segura, Luis M.
Issue Date2010
PublisherAcademic Press
CitationHormones and Behavior 58: 786- 791 (2010)
AbstractOvarian hormones exert anti-depressive and anxiolytic actions. In this study we have analyzed the effects of ovariectomy on the development of anxiety and depression-like behaviors and on cell proliferation in the hippocampus of mice submitted to chronic unpredictable stress. Animals submitted to stress 4 months after ovariectomy showed a significant increase in immobility behavior in the forced swimming test compared to animals submitted to stress 2 weeks after ovariectomy. In addition, long-term ovariectomy resulted in a significant decrease on the time spent in the open arms in the elevated plus-maze test compared to control animals. Stress did not significantly affect cell proliferation in the hilus of the dentate gyrus. However, ovariectomy resulted in a significant decrease in cell proliferation. These results indicate that long-term deprivation of ovarian hormones enhances the effect of chronic unpredictable stress on depressive- and anxiety-like behaviors in mice. Therefore, a prolonged deprivation of ovarian hormones may represent a risk factor for the development of depressive and anxiety symptoms after the exposure to stressful experiences. © 2010 Elsevier Inc.
URIhttp://hdl.handle.net/10261/62343
DOI10.1016/j.yhbeh.2010.07.014
Identifiersdoi: 10.1016/j.yhbeh.2010.07.014
issn: 0018-506X
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.