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Título: | Overexpression of the VAV proto-oncogene product is associated with B-cell chronic lymphocytic leukaemia displaying loss on 13q |
Autor: | Prieto-Sánchez, Rosario M.; Hernández, José Ángel; García, Juan L. CSIC ORCID CVN ; Gutiérrez, Norma Carmen; San Miguel, Jesús F. CSIC ORCID; Bustelo, Xosé R. CSIC ORCID ; Hernández, Jesús M. CSIC ORCID | Fecha de publicación: | 2006 | Editor: | Blackwell Publishing | Citación: | British Journal of Haematology 133(6): 642-645 (2006) | Resumen: | The expression of the VAV proto-oncogene in 57 patients with chronic myeloproliferative disease (CMD), B-cell acute lymphoblastic leukaemia (B-ALL) and B-cell non-Hodgkin Lymphoma (B-NHL), and 61 with B-cell chronic lymphocytic leukaemia (B-CLL) was analysed. VAV overexpression was observed in 19.5% of cases and 81% of VAV-positive tumours also displayed VAV phosphorylation. Overexpression was not observed in B-ALL or CMD, but 13% of B-NHL and 34.4% of B-CLL patients (P = 0.002) overexpressed VAV. The overexpression and phosphorylation of VAV was detected more frequently in 13q- chronic lymphocytic leukaemias (71.4%) versus other B-CLLs (23.4%, P = 0.001). Overexpression of VAV protein is a frequent event in patients with B-CLL displaying loss of 13q sequences. © 2006 Blackwell Publishing Ltd. | URI: | http://hdl.handle.net/10261/62280 | DOI: | 10.1111/j.1365-2141.2006.06094.x | Identificadores: | doi: 10.1111/j.1365-2141.2006.06094.x issn: 0007-1048 e-issn: 1365-2141 |
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Overexpression of the VAV.pdf | 153,92 kB | Adobe PDF | Visualizar/Abrir |
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