Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/61886
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Novel genomic imbalances in b-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogenetics |
Autor: | Hernández, Jesús M. CSIC ORCID ; García, Juan L. CSIC ORCID CVN ; Gutiérrez, Norma Carmen; Flores, Teresa; González, M. Belén; San Miguel, Jesús F. CSIC ORCID | Fecha de publicación: | 2001 | Editor: | Elsevier | Citación: | American Journal of Pathology 158(5): 1843-1850 (2001) | Resumen: | Splenic marginal zone lymphoma (SMZL) has recently been recognized in the World Health Organization classification of hematological diseases as distinct type of non-Hodgkin's lymphoma. In contrast to the well-established chromosomal changes associated with other B-cell non-Hodgkin's lymphoma, few genetic alterations have been found associated with SMZL. The aim of our study was to analyze by comparative genomic hybridization (CGH) the chromosomal imbalances in 29 patients with SMZL and to correlate these findings with clinical and biological characteristics and patient outcome. In 21 cases, cytogenetic studies were simultaneously performed. Most of the patients (83%) displayed genomic imbalances. A total of 111 DNA copy number changes were detected with a median of four abnormalities per case (range, 1 to 12). Gains (n = 92) were more frequent than losses (n = 16), while three high-level amplifications (3q26-q29, 5p11-p15, and 17q22-q25) were observed. The most frequent gains involved 3q (31%), 5q (28%), 12q and 20q (24% each), 9q (21%), and 4q (17%). Losses were observed in 7q (14%) and 17p (10%). SMZL patients with genetic losses had a shorter survival than the remaining SMZL patients (P < 0.05). In summary, chromosomal imbalances in regions 3q, 4q, 5q, 7q, 9q, 12q, and 20q have been detected by CGH in SMZL. Patients with SMZL displaying genetic losses by CGH had a short survival. | URI: | http://hdl.handle.net/10261/61886 | DOI: | 10.1016/S0002-9440(10)64140-5 | Identificadores: | doi: 10.1016/S0002-9440(10)64140-5 issn: 0002-9440 e-issn: 1525-2191 |
Aparece en las colecciones: | (IBMCC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
9
checked on 13-abr-2024
SCOPUSTM
Citations
78
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
61
checked on 29-feb-2024
Page view(s)
325
checked on 24-abr-2024
Download(s)
108
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.