Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/61846
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Synthesis and biophysical study of disassembling nanohybrid bioconjugates with a cubic octasilsesquioxane core

AutorTrastoy, Beatriz CSIC ORCID; Bonso, Daniel A.; Pérez-Ojeda, M. Eugenia CSIC; Jimeno, M. Luisa CSIC ORCID; Méndez-Ardoy, Alejandro CSIC ORCID; García Fernández, José Manuel CSIC ORCID; Chiara, José Luis CSIC ORCID ; Sundberg, Eric J.
Fecha de publicación2012
EditorJohn Wiley & Sons
CitaciónAdvanced Functional Materials 22 : 3191- 3201 (2012)
ResumenPolyhedral oligosilsesquioxanes (POSS) have recently attracted attention as scaffolds for the synthesis of multivalent bioconjugates. The synthesis of glycosyl-octasilsesquioxanes (glyco-POSS) using a copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition approach is reported. The problems associated with the use of bases or aqueous media in their preparation are investigated and a comprehensive study of the multivalent interaction between the mannosyl-octasilsesquioxanes and a model lectin, concanavalin A (Con A), using an array of complementary biophysical techniques is presented. The possibility to modulate the half-life of POSS conjugates in aqueous solution and the low toxicity of their constituent monomeric organosilanes offers an advantage over other scaffolds in vivo, preventing bioaccumulation and saturation of complementary receptors (lectins). Despite the hydrolysis in water, the octamannosyl-POSS studied shows a 50-fold higher binding affinity to Con A than methyl α-D-mannopyranoside. These experiments suggest that the novel glyco-POSS are attractive compounds for in vivo applications that require multivalent display of glycans.
URIhttp://hdl.handle.net/10261/61846
DOI10.1002/adfm.201200423
Identificadoresdoi: 10.1002/adfm.201200423
issn: 1616-301X
Aparece en las colecciones: (IIQ) Artículos
(CENQUIOR) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

SCOPUSTM   
Citations

34
checked on 13-mar-2024

WEB OF SCIENCETM
Citations

37
checked on 29-feb-2024

Page view(s)

344
checked on 18-mar-2024

Download(s)

119
checked on 18-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.