English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/61846
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Synthesis and biophysical study of disassembling nanohybrid bioconjugates with a cubic octasilsesquioxane core

AuthorsTrastoy, Beatriz ; Bonso, Daniel A.; Pérez-Ojeda, M. Eugenia ; Jimeno, M. Luisa ; Méndez-Ardoy, Alejandro ; García Fernández, José Manuel ; Chiara, José Luis ; Sundberg, Eric J.
Issue Date2012
PublisherJohn Wiley & Sons
CitationAdvanced Functional Materials 22 : 3191- 3201 (2012)
AbstractPolyhedral oligosilsesquioxanes (POSS) have recently attracted attention as scaffolds for the synthesis of multivalent bioconjugates. The synthesis of glycosyl-octasilsesquioxanes (glyco-POSS) using a copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition approach is reported. The problems associated with the use of bases or aqueous media in their preparation are investigated and a comprehensive study of the multivalent interaction between the mannosyl-octasilsesquioxanes and a model lectin, concanavalin A (Con A), using an array of complementary biophysical techniques is presented. The possibility to modulate the half-life of POSS conjugates in aqueous solution and the low toxicity of their constituent monomeric organosilanes offers an advantage over other scaffolds in vivo, preventing bioaccumulation and saturation of complementary receptors (lectins). Despite the hydrolysis in water, the octamannosyl-POSS studied shows a 50-fold higher binding affinity to Con A than methyl α-D-mannopyranoside. These experiments suggest that the novel glyco-POSS are attractive compounds for in vivo applications that require multivalent display of glycans.
Identifiersdoi: 10.1002/adfm.201200423
issn: 1616-301X
Appears in Collections:(IIQ) Artículos
(CENQUIOR) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.