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Chagasic patients are able to respond against a viral antigen from influenza virus

AuthorsLasso, Paola; Mesa, Diana; Bolaños, Natalia; Cuéllar, Adriana; Guzmán, Fanny; Cucunubá, Zulma M.; Rosas, Fernando; Velasco, Víctor; Thomas, María del Carmen; López López, Manuel Carlos; González, John M.; Puerta, Concepción J.
Issue Date24-Aug-2012
PublisherBioMed Central
CitationBMC Infectious Diseases. 24;12(1):198 (2012)
AbstractAbstract Background Trypanosoma cruzi, the etiological agent of Chagas’ disease, is an obligate intracellular parasite which induces a CD8+ T cell immune response with secretion of cytokines and release of cytotoxic granules. Although an immune-suppressive effect of T. cruzi on the acute phase of the disease has been described, little is known about the capacity of CD8+ T cell from chronic chagasic patients to respond to a non-T. cruzi microbial antigen. Methods In the present paper, the frequency, phenotype and the functional activity of the CD8+ T cells specific from Flu-MP*, an influenza virus epitope, were determined in 13 chagasic patients and 5 healthy donors. Results The results show that Flu-MP* peptide specific CD8+ T cells were found with similar frequencies in both groups. In addition, Flu-MP* specific CD8+ T cells were distributed in the early or intermediate/late differentiation stages without showing enrichment of a specific sub-population. The mentioned Flu-MP* specific CD8+ T cells from chagasic patients were predominately TEM (CCR7- CD62L-), producing IL-2, IFNγ, CD107a/b and perforin, and did not present significant differences when compared with those from healthy donors. Conclusions Our results support the hypothesis that there is no CD8+ T cell nonspecific immune-suppression during chronic Chagas disease infection. Nonetheless, other viral antigens must be studied in order to confirm our findings.
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