English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/6154
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 65 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título

Oscillation patterns in negative feedback loops

Autor Pigolotti, Simone; Krishna, Sandeep; Jensen, Mogens H.
Palabras clave Molecular Networks
Feedback loops
Oscillatory systems
Biochemical processes
Symbolic dynamics
Mathematical models
Fecha de publicación 17-abr-2007
EditorNational Academy of Sciences (U.S.)
Citación Proceedings of the National Academy of Sciences of the USA (PNAS) 104, 6533-6537 (2007)
ResumenOrganisms are equipped with regulatory systems that display a variety of dynamical behavior ranging from simple stable steady states, to switching and multistability, to oscillations. Earlier work has shown that oscillations in protein concentrations or gene expression levels are related to the presence of at least one negative feedback loop in the regulatory network. Here, we study the dynamics of a very general class of negative feedback loops. Our main result is that, when a single negative feedback loop dominates the dynamical behavior, the sequence of maxima and minima of the concentrations exhibit a pattern that uniquely identifies the interactions of the loop. This allows us to devise an algorithm to (i) test whether observed oscillating time series are consistent with a single underlying negative feedback loop, and if so, (ii) reconstruct the precise structure of the loop, i.e., the activating/repressing nature of each interaction. This method applies even when some variables are missing from the data set, or if the time series shows transients, like damped oscillations. We illustrate the relevance and the limits of validity of our method with three examples: p53-Mdm2 oscillations, circadian gene expression in cyanobacteria, and cyclic binding of cofactors at the estrogen-sensitive pS2 promoter.
Descripción 5 pages.-- ArXiv pre-print: http://arxiv.org/abs/q-bio/0611038.-- Final full-text version of the paper available at: http://dx.doi.org/10.1073/pnas.0610759104.-- Supporting information online at: http://www.pnas.org/content/104/16/6533/suppl/DC1.
URI http://hdl.handle.net/10261/6154
DOI10.1073/pnas.0610759104
ISSN0027-8424
Aparece en las colecciones: (IFISC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Oscillation_patterns.pdf267,42 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.