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Title

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

AuthorsFuente-Martín, Esther; García-Cáceres, C.; Granado, Miriam; Ceballos, María L. de ; Sánchez-Garrido, Miguel Ángel; Sarman, Beatrix; Liu, Z. W.; Dietrich, M. O.; Tena-Sempere, Manuel; Argente-Arizan, Pilar; Díaz, F.; Argente, Jesús; Horvath, T. L.; Chowen, Julie A.
Issue Date2012
PublisherAmerican Society for Clinical Investigation
CitationJournal of Clinical Investigation 122: 3900- 3913 (2012)
AbstractGlial cells perform critical functions that alter the metabolism and activity of neurons, and there is increasing interest in their role in appetite and energy balance. Leptin, a key regulator of appetite and metabolism, has previously been reported to influence glial structural proteins and morphology. Here, we demonstrate that metabolic status and leptin also modify astrocyte-specific glutamate and glucose transporters, indicating that metabolic signals influence synaptic efficacy and glucose uptake and, ultimately, neuronal function. We found that basal and glucose-stimulated electrical activity of hypothalamic proopiomelanocortin (POMC) neurons in mice were altered in the offspring of mothers fed a high-fat diet. In adulthood, increased body weight and fasting also altered the expression of glucose and glutamate transporters. These results demonstrate that whole-organism metabolism alters hypothalamic glial cell activity and suggest that these cells play an important role in the pathology of obesity.
URIhttp://hdl.handle.net/10261/61539
DOI10.1172/JCI64102
Identifiersdoi: 10.1172/JCI64102
issn: 0021-9738
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