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New synthesis and promising neuroprotective role in experimental ischemic stroke of ONO-1714

AuthorsPozo-Rodrigálvarez, Andrea ; Gradillas, Ana; Serrano, Julia ; Fernández Fernández, Ana Patricia ; Martínez-Murillo, Ricardo ; Pérez-Castells, J.
Issue Date2012
CitationEuropean Journal of Medicinal Chemistry 54: 439- 446 (2012)
AbstractIn an experimental permanent stroke model, we report here the contribution of ONO-1714 to brain damage prevention. Daily drug administration, twenty-one days prior to and two days after an experimental infarct, was performed by using mini-osmotic pumps (ALZET). Infarct volumes were assessed by image analysis of sequential coronal brain 1 mm 3 sections stained following the 2,3,5-triphenyltetrazolium chloride histological staining technique. Results of this study provide evidence of a significant reduction of the brain lesion size, suggesting ONO-1714 as a potential neuroprotective agent in stroke patients. ONO-1714 was prepared in our laboratory following a procedure which resulted in the supply of the desired compound in an easy and excellent yield. © 2012 Elsevier Masson SAS. All rights reserved.
Identifiersdoi: 10.1016/j.ejmech.2012.05.031
issn: 0223-5234
Appears in Collections:(IC) Artículos
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