English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/61466
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus

AuthorsTeruel, María; Martín, J. E.; Ortego-Centeno, N.; Jiménez-Alonso, Juan; Sánchez-Román, J.; Ramón, Enrique de; González-Escribano, María Francisca; Pons-Estel, B. A.; D'Alfonso, S.; Sebastiani, G. D.; Witte, Torsten; Bottini, N.; González-Gay, M. A.; Alarcón-Riquelme, M. E.; Martín, J.
Issue Date2012
CitationHuman Immunology 73: 107- 110 (2012)
AbstractThe red cell acid phosphatase (ACP1) gene, which encodes a low-molecular-weight phosphotyrosine phosphatase, has been suggested as a common genetic factor of autoimmunity. In the present study, we aim to investigate the possible association of ACP1 with the susceptibility of systemic lupus erythematosus (SLE). A total of 1,546 SLE patients and 1,947 healthy individuals from 4 Caucasians populations were included in the present study. Four single-nucleotide polymorphisms (SNPs) were genotyped in this study: rs10167992, rs11553742, rs7576247, and rs3828329. ACP1*A, ACP1*B, and ACP1*C codominant ACP1 alleles were determined using 2 of the SNPs and analyzed. After the meta-analysis test was performed, a significant association of rs11553742*T was observed (ppooled = 0.005, odds ratios = 1.37 [1.10-1.70]), retaining significance after multiple testing was applied (pFDR = 0.019). Our data indicate for first time the association of rs11553742*T with increased susceptibility in SLE patients. © 2012 American Society for Histocompatibility and Immunogenetics.
Identifiersdoi: 10.1016/j.humimm.2011.10.012
issn: 0198-8859
Appears in Collections:(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.