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Title

Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons

AuthorsMartín-Ibáñez, R.; Crespo, Empar; Esgleas, M.; Urbán, Noelia; Wang, B.; Waclaw, R.; Georgopoulos, K.; Martínez, Salvador; Campbell, K.; Vicario-Abejón, Carlos ; Alberch, J.; Chan, S.; Kastner, P.; Rubenstein, John L.; Canals, Josep María
Issue Date2012
PublisherMary Ann Liebert
CitationStem Cells and Development 21: 2239- 2251 (2012)
AbstractDevelopment of the nervous system is finely regulated by consecutive expression of cell-specific transcription factors. Here we show that Helios, a member of the Ikaros transcription factor family, is expressed in ectodermal and neuroectodermal-derived tissues. During embryonic development, Helios is expressed by several brain structures including the lateral ganglionic eminence (LGE, the striatal anlage); the cingulated, insular and retrosplenial cortex; the hippocampus; and the accessory olfactory bulb. Moreover, Helios is also expressed by Purkinje neurons during postnatal cerebellar development. Within the LGE, Helios expression follows a dynamic spatio-temporal pattern starting at embryonic stages (E14.5), peaking at E18.5, and completely disappearing during postnatal development. Helios is expressed by a small population of nestin-positive neural progenitor cells located in the subventricular zone as well as by a larger population of immature neurons distributed throughout the mantle zone. In the later, Helios is preferentially expressed in the matrix compartment, where it colocalizes with Bcl11b and Foxp1, well-known markers of striatal projection neurons. In addition, we observed that Helios expression is not detected in Dlx1/2 and Gsx2 null mutants, while its expression is maintained in Ascl1 mutants. These findings allow us to introduce a new transcription factor in the cascade of events that take part of striatal development postulating the existence of at least 4 different neural progenitors in the LGE. An Ascl1-independent but Gsx2-& Dlx1/2-dependent precursor will express Helios defining a new lineage for a subset of matrix striatal neurons. © 2012, Mary Ann Liebert, Inc.
URIhttp://hdl.handle.net/10261/61430
DOI10.1089/scd.2011.0607
Identifiersdoi: 10.1089/scd.2011.0607
issn: 1547-3287
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