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| Título: | Chemical probes for the recognition of cannabinoid receptors in native systems |
Autor: | Martín-Couce, L.; Martín-Fontecha, Mar; Palomares, O.; Mestre, Leyre CSIC ORCID ; Cordomí, Arnau; Hernangómez-Herrero, Miriam CSIC; Palma, S.; Pardo, L.; Guaza, Carmen CSIC ORCID ; López-Rodríguez, María L.; Ortega-Gutiérrez, S. | Palabras clave: | Bioorganic chemistry Cannabinoid ligands Chemical probes Membrane proteins Protein models |
Fecha de publicación: | 9-jul-2012 | Editor: | John Wiley & Sons | Citación: | Angewandte Chemie - International Edition 51(28): 6896-6899 (2012) | Resumen: | Receptors made visible: The described biotin-tagged small-molecule probes with excellent affinities for the CB 1 and CB 2 cannabinoid receptors (CB 1R and CB 2R) enable direct visualization of these receptors in native cellular systems, including neurons (see picture), microglia, and immune cells. This method could overcome some of the limitations of current methodologies and may help to dissect the complexity of the endogenous cannabinoid system. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | Versión del editor: | http://doi.org/10.1002/anie.201200467 | URI: | http://hdl.handle.net/10261/61387 | DOI: | 10.1002/anie.201200467 | Identificadores: | doi: 10.1002/anie.201200467 issn: 1433-7851 |
| Aparece en las colecciones: | (IC) Artículos |
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| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
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