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Title

Tau phosphorylation by GSK3 in different conditions

AuthorsÁvila, Jesús ; León-Espinosa, G.; García, Esther; García-Escudero, Vega ; Hernández, F.; DeFelipe, Javier
Issue Date2012
PublisherHindawi Publishing Corporation
CitationInternational Journal of Alzheimer Disease (2012)
AbstractAlmost a 20% of the residues of tau protein are phosphorylatable amino acids: serine, threonine, and tyrosine. In this paper we comment on the consequences for tau of being a phosphoprotein. We will focus on serine/threonine phosphorylation. It will be discussed that, depending on the modified residue in tau molecule, phosphorylation could be protective, in processes like hibernation, or toxic like in development of those diseases known as tauopathies, which are characterized by an hyperphosphorylation and aggregation of tau. © Copyright 2012 Jess Avila et al.
URIhttp://hdl.handle.net/10261/61382
DOI10.1155/2012/578373
Identifiersdoi: 10.1155/2012/578373
issn: 2090-0252
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