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Title

Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress

AuthorsCalmarza-Font, Isabel ; Lagunas, Natalia; García-Segura, Luis M.
Issue Date2012
PublisherElsevier
CitationBehavioural Brain Research 227: 287- 290 (2012)
AbstractEstradiol has antidepressive and anxiolytic actions. However, its therapeutic use is limited by its peripheral effects. Selective estrogen receptor modulators may represent an alternative to estradiol for the treatment of depressive symptoms. Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress. © 2011 Elsevier B.V.
URIhttp://hdl.handle.net/10261/61240
DOI10.1016/j.bbr.2011.10.036
Identifiersdoi: 10.1016/j.bbr.2011.10.036
issn: 0166-4328
Appears in Collections:(IC) Artículos
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