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dc.contributor.authorLópez-Casas, Pedro P.-
dc.contributor.authorMizrak, Sefika C.-
dc.contributor.authorLópez-Fernández, Luis A.-
dc.contributor.authorPaz, María-
dc.contributor.authorRooij, Dirk G. de-
dc.contributor.authorDel Mazo, Jesús-
dc.date.accessioned2012-11-23T13:36:48Z-
dc.date.available2012-11-23T13:36:48Z-
dc.date.issued2012-01-
dc.identifier.citationReproductive Toxicology 33(1):106-115(2012)es_ES
dc.identifier.issn0890-6238-
dc.identifier.urihttp://hdl.handle.net/10261/61018-
dc.description10 páginas, 6 figuras, 3 tablas -- PAGS nros. 106-115es_ES
dc.description.abstractEnvironmental contaminants considered endocrine disruptors have been shown to affect testis development and function but the mechanisms of action are not clear. We now have analyzed the effects on the transcriptome in testes of mice exposed to mono-(2-ethylhexyl)-phthalate (9.2; 46.3 or 92.7 mg/kg/d), zearalenone (1.3; 3.9 or 6.6 mg/kg/d), lindane (16.6; 32.2 or 64.4 mg/kg/d), bisphenol-A (0.16; 16 or 64 mg/kg/d) or 17β-estradiol (0.006; 0.012 or 0.048 mg/kg/d). The compounds were orally administered in the drinking water during distinct developmental periods: (A) mothers were exposed only during the two weeks before mating; (B) the exposure was continued during pregnancy until birth or (C) exposure was continued for a further four weeks after birth. Testes were studied at four weeks of age. Mono-(2-ethylhexyl)-phthalate and zearalenone, both produced specific alterations of gene signatures. Interestingly, this was irrespective of the concentration of the toxicant or the developmental period during which exposure occurredes_ES
dc.description.sponsorshipThis work was supported by the EC (grant QLK4-CT-2002-02403), CEFIC-LRi, MICINN (FIS PI071007) and PIE (201020E016). LALF was supported by a Miguel Servet grant from Instituto de Salud Carlos III (CP06/00267)es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsopenAccesses_ES
dc.subjectEndocrine disruptores_ES
dc.subjectTestises_ES
dc.subject17β-Estradioles_ES
dc.subjectLindanees_ES
dc.subjectBisphenol-Aes_ES
dc.subjectMono-ethylhexyl phthalatees_ES
dc.subjectZearalenonees_ES
dc.subjectDNA microarrayses_ES
dc.subjectGene expression profilees_ES
dc.titleThe Effects of Different Endocrine Disruptors Defining Compound-Specific Alterations of Gene Expression Profiles in the Developing Testis.es_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.reprotox.2011.12.012-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.reprotox.2011.12.012es_ES
dc.identifier.e-issn1873-1708-
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