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Fitness of thepMV158 replicon in Streptococcus pneumoniae

AuthorsHernández-Arriaga, A.M. ; Espinosa, Manuel ; Solar, Gloria del
KeywordsPlasmid stability
Host-plasmid fitness
Genetic load
Issue DateMar-2012
CitationPlasmid, 67 (2) : 162-166 (2012)
AbstractPromiscuous, rolling-circle replication plasmid pMV158 determines tetracycline resistance to its host and can be mobilized by conjugation. Plasmid pLS1 is a deletion derivative of pMV158 that has lost its conjugative mobilization ability. Both plasmids replicate efficiently and are stably inherited in Streptococcus pneumoniae. We have analyzed the effect of pMV158 and pLS1 carriage on the bacterial growth rate. Whereas the parental plasmid does not significantly modify the cell doubling time, pLS1 slows down the growth of the bacterial host by 8–9%. The bases of the differential burden caused by pMV158 and pLS1 carriage are not yet understood. The negligible cost of the pMV158 parental natural plasmid on the host might explain the prevalence of small, multicopy, rolling-circle replication plasmids, even though they lack any selectable trait
Description15 p.-3 fig.
Publisher version (URL)http://dx.doi.org/10.1016/j.plasmid.2012.01.005
Appears in Collections:(CIB) Artículos
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