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Serum insulin-like growth factor I regulates brain amyloid-β levels

AuthorsCarro, Eva; Trejo, José L. ; Gómez-Isla, T.; LeRoith, D.; Torres Alemán, Ignacio
Issue Date2002
PublisherNature Publishing Group
CitationNature Medicine 8: 1390- 1397 (2002)
AbstractLevels of insulin-like growth factor I (IGF-I), a neuroprotective hormone, decrease in serum during aging, whereas amyloid-β (Aβ), which is involved in the pathogenesis of Alzheimer disease, accumulates in the brain. High brain Aβ levels are found at an early age in mutant mice with low circulating IGF-I, and Aβ burden can be reduced in aging rats by increasing serum IGF-I. This opposing relationship between serum IGF-I and brain Aβ levels reflects the ability of IGF-I to induce clearance of brain Aβ, probably by enhancing transport of Aβ carrier proteins such as albumin and transthyretin into the brain. This effect is antagonized by tumor necrosis factor-α, a proinflammatory cytokine putatively involved in dementia and aging. Because IGF-I treatment of mice overexpressing mutant amyloid markedly reduces their brain Aβ burden, we consider that circulating IGF-I is a physiological regulator of brain amyloid levels with therapeutic potential.
Identifiersdoi: 10.1038/nm793
issn: 1078-8956
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