English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/60916
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Serum insulin-like growth factor I regulates brain amyloid-β levels

AuthorsCarro, Eva; Trejo, José L. ; Gómez-Isla, T.; LeRoith, D.; Torres Alemán, Ignacio
Issue Date2002
PublisherNature Publishing Group
CitationNature Medicine 8: 1390- 1397 (2002)
AbstractLevels of insulin-like growth factor I (IGF-I), a neuroprotective hormone, decrease in serum during aging, whereas amyloid-β (Aβ), which is involved in the pathogenesis of Alzheimer disease, accumulates in the brain. High brain Aβ levels are found at an early age in mutant mice with low circulating IGF-I, and Aβ burden can be reduced in aging rats by increasing serum IGF-I. This opposing relationship between serum IGF-I and brain Aβ levels reflects the ability of IGF-I to induce clearance of brain Aβ, probably by enhancing transport of Aβ carrier proteins such as albumin and transthyretin into the brain. This effect is antagonized by tumor necrosis factor-α, a proinflammatory cytokine putatively involved in dementia and aging. Because IGF-I treatment of mice overexpressing mutant amyloid markedly reduces their brain Aβ burden, we consider that circulating IGF-I is a physiological regulator of brain amyloid levels with therapeutic potential.
URIhttp://hdl.handle.net/10261/60916
DOI10.1038/nm793
Identifiersdoi: 10.1038/nm793
issn: 1078-8956
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.