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dc.contributor.authorTiana, Guidoen_US
dc.contributor.authorKrishna, Sandeepen_US
dc.contributor.authorPigolotti, Simoneen_US
dc.contributor.authorJensen, Mogens H.en_US
dc.contributor.authorSneppen, K.en_US
dc.date.accessioned2008-07-22T15:05:47Z-
dc.date.available2008-07-22T15:05:47Z-
dc.date.issued2007-05-18en_US
dc.identifier.citationPhysical Biology 4, R1-R17 (2007)en_US
dc.identifier.issn1478-3975 (Online)-
dc.identifier.urihttp://hdl.handle.net/10261/6083-
dc.descriptionArXiv pre-print: http://arxiv.org/abs/q-bio/0703047.-- Final full-text version of the paper available at: http://dx.doi.org/10.1088/1478-3975/4/2/R01.-
dc.descriptionPMID: 17664651-
dc.description.abstractThe development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a framework of simple mathematical models. We focus on three eukaryotic genetic regulatory networks which show ultradian oscillations, with a time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53) and immune response (NF-κB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.en_US
dc.description.sponsorshipSK, MHJ and KS acknowledge support from the Danish National Research Foundation and Villum Kann Rasmussen Foundation. GT acknowledges support from the FIRB 2003 program of the Italian Ministry for University and Scientific Research.-
dc.format.extent2373 bytes-
dc.format.extent552687 bytes-
dc.format.mimetypetext/plain-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherInstitute of Physics Publishing-
dc.rightsopenAccess-
dc.source.urihttp://dx.doi.org/10.1088/1478-3975/4/2/R01-
dc.subjectMolecular Networks-
dc.subjectQuantitative Biology-
dc.titleOscillations and temporal signalling in cellsen_US
dc.typeArtículoen_US
dc.identifier.doi10.1088/1478-3975/4/2/R01-
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