English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/6083
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 80 veces en Web of Knowledge®  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Oscillations and temporal signalling in cells
Autor : Tiana, Guido; Krishna, Sandeep; Pigolotti, Simone; Jensen, Mogens H.; Sneppen, K.
Palabras clave : Molecular Networks
Quantitative Biology
Fecha de publicación : 18-may-2007
Editor: Institute of Physics Publishing
Citación : Physical Biology 4, R1-R17 (2007)
Resumen: The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a framework of simple mathematical models. We focus on three eukaryotic genetic regulatory networks which show ultradian oscillations, with a time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53) and immune response (NF-κB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.
Descripción : ArXiv pre-print: http://arxiv.org/abs/q-bio/0703047.-- Final full-text version of the paper available at: http://dx.doi.org/10.1088/1478-3975/4/2/R01.
PMID: 17664651
URI : http://hdl.handle.net/10261/6083
DOI: 10.1088/1478-3975/4/2/R01
ISSN: 1478-3975 (Online)
Aparece en las colecciones: (IFISC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Pigo_physbio.pdf539,73 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.