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Oscillations and temporal signalling in cells

AutorTiana, Guido; Krishna, Sandeep; Pigolotti, Simone; Jensen, Mogens H.; Sneppen, K.
Palabras claveMolecular Networks
Quantitative Biology
Fecha de publicación18-may-2007
EditorInstitute of Physics Publishing
CitaciónPhysical Biology 4, R1-R17 (2007)
ResumenThe development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce oscillations in gene expression or protein concentration using a framework of simple mathematical models. We focus on three eukaryotic genetic regulatory networks which show ultradian oscillations, with a time period of the order of hours, and involve, respectively, proteins important for development (Hes1), apoptosis (p53) and immune response (NF-κB). We argue that underlying all three is a common design consisting of a negative feedback loop with time delay which is responsible for the oscillatory behaviour.
DescripciónArXiv pre-print: http://arxiv.org/abs/q-bio/0703047.-- Final full-text version of the paper available at: http://dx.doi.org/10.1088/1478-3975/4/2/R01.
PMID: 17664651
URIhttp://hdl.handle.net/10261/6083
DOI10.1088/1478-3975/4/2/R01
ISSN1478-3975 (Online)
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