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Interactome data and databases: Different types of protein interaction

AuthorsDe Las Rivas, Javier ; Luis, Alberto de
Issue Date2004
PublisherHindawi Publishing Corporation
John Wiley & Sons
CitationComparative and Functional Genomics 5(2): 173-178 (2004)
AbstractIn recent years, the biomolecular sciences have been driven forward by overwhelming advances in new biotechnological high-throughput experimental methods and bioinformatic genome-wide computational methods. Such breakthroughs are producing huge amounts of new data that need to be carefully analysed to obtain correct and useful scientific knowledge. One of the fields where this advance has become more intense is the study of the network of 'protein-protein interactions', i.e. the 'interactome'. In this short review we comment on the main data and databases produced in this field in last 5 years. We also present a rationalized scheme of biological definitions that will be useful for a better understanding and interpretation of 'what a protein-protein interaction is' and 'which types of protein-protein interactions are found in a living cell'. Finally, we comment on some assignments of interactome data to defined types of protein interaction and we present a new bioinformatic tool called APIN (Agile Protein Interaction Network browser), which is in development and will be applied to browsing protein interaction databases.
Description6 páginas, 1 figura.-- Conference review.-- This is an open access article distributed under the Creative Commons Attribution License.
Publisher version (URL)http://dx.doi.org/10.1002/cfg.377
Identifiersdoi: 10.1002/cfg.377
issn: 1531-6912
e-issn: 1532-6268
Appears in Collections:(IBMCC) Artículos
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