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Título: | Interactome data and databases: Different types of protein interaction |
Autor: | De Las Rivas, Javier CSIC ORCID CVN ; Luis, Alberto de CSIC | Fecha de publicación: | 2004 | Editor: | Hindawi Publishing Corporation John Wiley & Sons |
Citación: | Comparative and Functional Genomics 5(2): 173-178 (2004) | Resumen: | In recent years, the biomolecular sciences have been driven forward by overwhelming advances in new biotechnological high-throughput experimental methods and bioinformatic genome-wide computational methods. Such breakthroughs are producing huge amounts of new data that need to be carefully analysed to obtain correct and useful scientific knowledge. One of the fields where this advance has become more intense is the study of the network of 'protein-protein interactions', i.e. the 'interactome'. In this short review we comment on the main data and databases produced in this field in last 5 years. We also present a rationalized scheme of biological definitions that will be useful for a better understanding and interpretation of 'what a protein-protein interaction is' and 'which types of protein-protein interactions are found in a living cell'. Finally, we comment on some assignments of interactome data to defined types of protein interaction and we present a new bioinformatic tool called APIN (Agile Protein Interaction Network browser), which is in development and will be applied to browsing protein interaction databases. | Descripción: | 6 páginas, 1 figura.-- Conference review.-- This is an open access article distributed under the Creative Commons Attribution License. | Versión del editor: | http://dx.doi.org/10.1002/cfg.377 | URI: | http://hdl.handle.net/10261/60686 | DOI: | 10.1002/cfg.377 | Identificadores: | doi: 10.1002/cfg.377 issn: 1531-6912 e-issn: 1532-6268 |
Aparece en las colecciones: | (IBMCC) Artículos |
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Interactome data.pdf | 144,57 kB | Adobe PDF | Visualizar/Abrir |
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