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Synthesis and characterization of a paramagnetic sialic acid conjugate as probe for magnetic resonance applications

AuthorsBini, David; Gregori, María ; Cosentino, U.; Moro, G.; Canales, Ángeles ; Capitoli, A.; Jiménez-Barbero, Jesús ; Cipolla, Laura
KeywordsSialic acid
Molecular modelling
Magnetic Resonance Imaging
Paramagnetic Relaxation Enhancement
Issue DateMay-2012
CitationCarbohydrate Research, 354 (1) : 21-31 (2012)
AbstractMagnetic Resonance Imaging (MRI) using paramagnetic systems as contrast agents is receiving increased attention as diagnostic tool in the clinic. At the same time, NMR of paramagnetic systems can also be applied in biochemical fields; for example, the use of Paramagnetic Relaxation Enhancement (PRE) allows structure refinement and the analysis of transient dynamic processes involved in macromolecular complex formation. Herein we report the synthesis and computational characterization of a new DOTA-like sialic acid conjugate, which can be used both in MRI and PRE applications when coordinated to a suitable paramagnetic metal
Description11 páginas, 8 figuras, 4 tablas, 3 esquemas -- PAGS nros. 21-31
Publisher version (URL)http://dx.doi.org/10.1016/j.carres.2012.03.002
Appears in Collections:(CIB) Artículos
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