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Title

The MRL proteins: Adapting cell adhesion, migration and growth

AuthorsColó, Georgina P. ; Lafuente, Esther M.; Teixidó, Joaquín
KeywordsMRL family
RIAM
Lamellipodin
MIG-10
Pico
Issue DateNov-2012
PublisherElsevier
CitationEuropean Journal of Cell Biology 91(11-12):861-868(2012)
AbstractMIG-10, RIAM and Lamellipodin (Lpd) are the founding members of the MRL family of multi-adaptor molecules. These proteins have common domain structures but display distinct functions in cell migration and adhesion, signaling, and in cell growth. The binding of RIAM with active Rap1 and with talin provides these MRL molecules with important regulatory roles on integrin-mediated cell adhesion and migration. Furthermore, RIAM and Lpd can regulate actin dynamics through their binding to actin regulatory Ena/VASP proteins. Recent data generated with the Drosophila MRL ortholog called Pico and with RIAM in melanoma cells indicate that these proteins can also regulate cell growth. As MRL proteins represent a relatively new family, many questions on their structure–function relationships remain unanswered, including regulation of their expression, post-translational modifications, new interactions, involvement in signaling and their knockout mice phenotype
Description8 páginas, 2 figuras, 1 tabla -- PAGS nros. 861-868
Publisher version (URL)http://dx.doi.org/10.1016/j.ejcb.2012.03.001
URIhttp://hdl.handle.net/10261/60467
DOI10.1016/j.ejcb.2012.03.001
ISSN0171-9335
E-ISSN1618-1298
Appears in Collections:(CIB) Artículos
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