Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/60365
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Different emotional disturbances in two experimental models of temporal Lobe Epilepsy in rats |
Autor: | Inostroza, Marion CSIC; Cid Ledesma, Elena CSIC ORCID; Menéndez de la Prida, Liset CSIC ORCID ; Sandi, Carmen CSIC ORCID | Fecha de publicación: | 2012 | Editor: | Public Library of Science | Citación: | PLoS ONE 7 (2012) | Resumen: | Affective symptoms such as anxiety and depression are frequently observed in patients with epilepsy. The mechanisms of comorbidity of epilepsy and affective disorders, however, remain unclear. Diverse models are traditionally used in epilepsy research, including the status epilepticus (SE) model in rats, which are aimed at generating chronic epileptic animals; however, the implications of different SE models and rat strains in emotional behaviors has not been reported. To address this issue, we examined the emotional sequelae of two SE models of temporal lobe epilepsy (TLE) - the lithium-pilocarpine (LIP) model and the kainic acid (KA) model - in two different rat strains (Wistar and Sprague-Dawley), which differ significantly in the pattern and extent of TLE-associated brain lesions. We found differences between LIP- and KA-treated animals in tests for depression-like and anxiety-like behaviors, as well as differences in plasma corticosterone levels. Whereas only LIP-treated rats displayed increased motivation to consume saccharin, both SE models led to reduced motivation for social contact, with LIP-treated animals being particularly affected. Evaluation of behavior in the open field test indicated very low levels of anxiety in LIP-treated rats and a mild decrease in KA-treated rats compared to controls. After exposure to a battery of behavioral tests, plasma corticosterone levels were increased only in LIP-treated animals. This hyperactivity in the hypothalamus-pituitary-adrenocortical (HPA) axis was highly correlated with performance in the open field test and the social interaction test, suggesting that comorbidity of epilepsy and emotional behaviors might also be related to other factors such as HPA axis function. Our results indicate that altered emotional behaviors are not inherent to the epileptic condition in experimental TLE; instead, they likely reflect alterations in anxiety levels related to model-dependent dysregulation of the HPA axis. © 2012 Inostroza et al. | URI: | http://hdl.handle.net/10261/60365 | DOI: | 10.1371/journal.pone.0038959 | Identificadores: | doi: 10.1371/journal.pone.0038959 issn: 1932-6203 |
Aparece en las colecciones: | (IC) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
22
checked on 29-mar-2024
SCOPUSTM
Citations
49
checked on 18-abr-2024
WEB OF SCIENCETM
Citations
49
checked on 29-feb-2024
Page view(s)
319
checked on 19-abr-2024
Download(s)
97
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.