English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/60335
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety

AuthorsMaya, Ana B. S.; Gajate, Consuelo; Mollinedo, Faustino
Issue Date2005
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 48(2): 556-568 (2005)
AbstractBy synthesis and biological studies of new naphthalene analogues of combretastatins, we have found that the naphthalene is a good surrogate for the isovanillin moiety (3-hydroxy-4-methoxyphenyl) of combretastatin A-4, always generating highly cytotoxic analogues when combined with the 3,4,5-trimethoxyphenyl or related systems. On the other hand, when the naphthalene replaces the 3,4,5-trimethoxyphenyl moiety, the cytotoxic activity is largely decreased. The most cytotoxic naphthalene analogues of combretastatins, which also produce inhibition of tubulin polymerization, exerted their antimitotic effects through microtubule network disruption and subsequent G2/M arrest of the cell cycle in human cancer cells.
Identifiersdoi: 10.1021/jm0310737
issn: 0022-2623
e-issn: 1520-4804
Appears in Collections:(IBMCC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.