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http://hdl.handle.net/10261/60289
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dc.contributor.author | Barrena, Susana | - |
dc.contributor.author | Almeida, Julia | - |
dc.contributor.author | López, Antonio | - |
dc.contributor.author | Rasillo, Ana | - |
dc.contributor.author | Sayagués, José María | - |
dc.contributor.author | Rivas, Rosa Ana | - |
dc.contributor.author | Gutiérrez, María Laura | - |
dc.contributor.author | Ciudad, Juana | - |
dc.contributor.author | Flores, Teresa | - |
dc.contributor.author | Caballero, Maria Dolores | - |
dc.contributor.author | Orfao, Alberto | - |
dc.date.accessioned | 2012-11-15T11:07:33Z | - |
dc.date.available | 2012-11-15T11:07:33Z | - |
dc.date.issued | 2011 | - |
dc.identifier | doi: 10.1111/j.1365-2559.2011.03804.x | - |
dc.identifier | issn: 0309-0167 | - |
dc.identifier | e-issn: 1365-2559 | - |
dc.identifier.citation | Histopathology 58(6): 906-918 (2011) | - |
dc.identifier.uri | http://hdl.handle.net/10261/60289 | - |
dc.description.abstract | [Aims]: To establish the utility of flow cytometry (FCM) for screening and diagnosis of B cell non-Hodgkin lymphoma (B-NHL) from lymphoid tissue samples obtained by fine-needle aspiration (FNA). [Methods and results]: We compared prospectively FCM versus cytology/histology analysis of FNA samples for the diagnostic screening and further World Health Organization (WHO) subclassification of B-NHL. FCM and cytology showed a high degree of agreement (93%); however, diagnosis of reactive processes (RP), B-NHL and T-NHL by FCM showed higher sensitivity than cytology (92-100% versus 64-94%, respectively), without false positive NHL cases. The antibody combination used did not allow a positive diagnosis of Hodgkin lymphoma as distinct from a RP. A high concordance rate was found between FCM and histopathology (74%) in subtyping B-NHL. In this regard, mantle-cell lymphoma and chronic lymphocytic leukaemia/small lymphocytic lymphoma showed the highest degree of agreement (100% concordant rates). In turn, FCM showed higher sensitivity/specificity in classifying follicular lymphoma (FL) and large B cell lymphomas, while the opposite occurred for marginal-zone and lymphoplasmacytic lymphomas. [Conclusions]: FCM enhances the diagnostic ability of FNA cytology, playing a crucial role in a rapid and accurate differential diagnosis between RP, B-NHL and T-NHL. In addition, immunophenotyping of FNA samples contributes to a more precise subclassification of B-NHL when combined with histopathology and genetic/molecular data. © 2011 Blackwell Publishing Limited. | - |
dc.description.sponsorship | This work has been supported partially by the RTICC RD06 ⁄ 0020 ⁄ 0035-FEDER, and FIS 08 ⁄ 90881 grants, from the Fondo de Investigación Sanitaria, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid, Spain. JM Sayagués is supported by CP05 ⁄ 00321 grant, from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid, Spain. | - |
dc.language.iso | eng | - |
dc.publisher | Blackwell Publishing | - |
dc.rights | closedAccess | - |
dc.title | Flow cytometry immunophenotyping of fine-needle aspiration specimens: Utility in the diagnosis and classification of non-Hodgkin lymphomas | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1111/j.1365-2559.2011.03804.x | - |
dc.date.updated | 2012-11-15T11:07:33Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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