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Enhancement of antiproliferative activity by molecular simplification of catalpol

AuthorsGarcía, Celina; Ríos-Luci, Carla; Montero, Juan Carlos ; Pandiella, Atanasio
Issue Date2010
CitationBioorganic and Medicinal Chemistry 18(7): 2515-2523 (2010)
AbstractTwo iridoid scaffolds were synthesized enantioselectively using as key step an l-proline-catalyzed α-formyl oxidation. The in vitro antiproliferative activities were evaluated against a representative panel of human solid tumor cell lines. Both iridoids induced considerably growth inhibition in the range 0.38-1.86 μM. Cell cycle studies for these compounds showed the induction of cell cycle arrest at the G1 phase. This result was consistent with a decrease in the expression of cyclin D1. Damaged cells underwent apoptosis as indicated by specific Annexin V staining. © 2010 Elsevier Ltd. All rights reserved.
Identifiersdoi: 10.1016/j.bmc.2010.02.044
issn: 0968-0896
Appears in Collections:(IBMCC) Artículos
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