English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/59998
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Central adaptation to odorants depends on PI3K levels in local interneurons of the antennal lobe

AuthorsAcebes-Vindel, José Ángel ; Devaud, J. M.; Arnés, Mercedes ; Ferrús, Alberto
Issue Date2012
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 32: 417- 422 (2012)
AbstractWe have previously shown that driving PI3K levels up or down leads to increases or reductions in the number of synapses, respectively. Using these tools to assay their behavioral effects in Drosophila melanogaster, we showed that a loss of synapses in two sets of local interneurons, GH298 and krasavietz, leads to olfaction changes toward attraction or repulsion, while the simultaneous manipulation of both sets of neurons restored normal olfactory indexes. We show here that olfactory central adaptation also requires the equilibrated changes in both sets of local interneurons. The same genetic manipulations directed to projection (GH146) or mushroom body (201Y, MB247) neurons did not affect adaptation. Also, we show that the equilibrium is a requirement for the glomerulus-specific size changes which are a morphological signature of central adaptation. Since the two sets of local neurons are mostly, although not exclusively, inhibitory (GH298) and excitatory (krasavietz), we interpret that the normal phenomena of sensory perception, measured as an olfactory index, and central adaptation rely on an inhibition/excitation ratio. © 2012 the authors.
URIhttp://hdl.handle.net/10261/59998
DOI10.1523/JNEUROSCI.2921-11.2012
Identifiersdoi: 10.1523/JNEUROSCI.2921-11.2012
issn: 0270-6474
Appears in Collections:(IC) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.